Restriction fragment length polymorphism of the insulin gene in diabetes mellitus.

The Soluble Carrier 30 A8 (SLC30A8) Gene Polymorphism and Risk of Diabetes Mellitus Type 2 in Eastern Azerbijan Population of Iran

Type 2 Diabetes Mellitus (T2D) is the most common metabolic disease demonstrating itself by hyper- glycemia, due to impaired insulin secretion or action. Recently, Whole-Genome Association studies have revealed the role of several new genes responsible for T2D. One of the most studied genes is SLC30A8 (Zn-T8) which is exclusively expressed in pancreatic ?-cells and participates in insulin stora...

G22A Polymorphism of Adenosine Deaminase and its Association with Biochemical Characteristics of Gestational Diabetes Mellitus in an Iranian Population

Adenosine deaminase (ADA) is an important regulator of insulin action. The single nucleotide polymorphism (SNP) G22A in the ADA gene decreases enzymatic activity of ADA. The aim of this study was to investigate the relationship between the SNP G22A and blood glycemic control, insulin resistance, and obesity of gestational diabetes mellitus (GDM) patients in an Iranian population. SNP G22A was d...

Possible Correlation Between Non-Insulin Dependant Diabetes Mellitus (NIDDM) and Restriction Fragment Length Polymorphism (RFLP) of the 5′-Flanking Region of Insulin Gene in Korean Diabetic Population

ASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK

Background: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes that was classically characterized by pancreatic β-cell dysfunction. Changes in circadian patterns is one of the reasons which can increase the occurrence of diabetes. Melatonin is one of the biological molecules which plays an important role in regulating the circadian clock and also an inhibitory effect on insulin...

Detection of Cytotoxic T-Lymphocyte Associated Antigen-4 Gene Polymorphism in Type 1 Diabetes Mellitus.

Type 1 diabetes is one of the most common chronic childhood illnesses. Interplay between genetic susceptibility and environmental factors is thought to provide the fundamental element for the disease. It has been shown that more than 40 genetic loci are associated with T1DM. Important one among these is the CTLA-4. This work aimed to detect Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4) g...